Handbook of capillary and microchip electrophoresis and associated microtechniques (3rd Edn). Advances in microchip liquid chromatography. Towards fully integrated liquid chromatography on a chip: evolution and evaluation. Microfluidic single-cell analysis - toward integration and total on-chip analysis. Cell–cell interactions: taking cues from the neighbors. Deciphering cell–cell interactions and communication from gene expression. Monolithic microfabricated valves and pumps by multilayer soft lithography. A., Chou, H.-P., Thorsen, T., Scherer, A. Human mammalian cell sorting using a highly integrated micro-fabricated fluorescence-activated cell sorter (microFACS). Digital microfluidics for cell-based assays. Droplet microfluidic technology for single-cell high-throughput screening. Microfluidic control of cell pairing and fusion. Microfluidic single-cell mRNA isolation and analysis. Microfluidic platforms for single-cell analysis. Visualization of streams of small organic molecules in continuous-flow electrophoresis. New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection. Autonomous reagent-based microfluidic pH sensor platform. Reconfigurable system for automated optimization of diverse chemical reactions. A robotic platform for flow synthesis of organic compounds informed by AI planning. Automated extraction of chemical synthesis actions from experimental procedures. Lab-on-a-chip: microfluidics in drug discovery. A programmable and reconfigurable microfluidic chip. Surface-directed liquid flow inside microchannels. A reconfigurable microfluidics platform for microparticle separation and fluid mixing. SmartBuild–A truly plug-n-play modular microfluidic system. A truly Lego®-like modular microfluidics platform. Digital microfluidics: is a true lab-on-a-chip possible? Microfluid.
Thermocapillarity in microfluidics - a review. Electrohydrodynamics and dielectrophoresis in microsystems: scaling laws. Droplet actuation by electrowetting-on-dielectric (EWOD): a review. Electro-actuated valves and self-vented channels enable programmable flow control and monitoring in capillary-driven microfluidics. Miniaturized total chemical analysis systems: A novel concept for chemical sensing. A gas chromatographic air analyzer fabricated on a silicon wafer. We review existing technologies that can dynamically control microscale flows, suggest additional physical mechanisms that could be leveraged towards the goal of reconfigurable microfluidics and highlight the importance of these efforts for the broad scientific community. We describe the ideal fully reconfigurable microfluidic device that can change its shape and function dynamically, which would allow researchers to tune a microscale experiment with the capacity to make real-time decisions. In this Perspective, we highlight that reconfigurability and programmability of microfluidic platforms can support new functionalities that are beyond the reach of current lab-on-a-chip systems. However, existing microfluidic channel networks are typically designed for the implementation of a single function or a well-defined protocol and do not allow the flexibility and real-time experimental decision-making essential to many scientific applications. Lab-on-a-chip devices leverage microfluidic technologies to enable chemical and biological processes at small scales.
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